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  • UGT1A1 promoter polymorphis...
    Fretzayas, Andrew; Kitsiou, Sofia; Tsezou, Aspasia; Alexaki, Augustina; Nicolaidou, Polyxeni

    Scandinavian journal of infectious diseases, 2006, Letnik: 38, Številka: 6-7
    Journal Article

    We describe 4 jaundiced neonates with acute pyelonephritis of whom family history was positive for or pointed to Gilbert's syndrome (GS). Uridine diphosphate glucuronosyltransferase 1A1 (UGT-1A1), (TA)7 polymorphism, associated with GS was found in these neonates. We suggest that extended (TA)7 promoter, acting as a predisposing factor, contributes substantially to hyperbilirubinaemia seen in a number of neonates with urinary tract infections (UTIs).