Akademska digitalna zbirka SLovenije - logo
E-viri
Celotno besedilo
Recenzirano Odprti dostop
  • Cerebellar deep brain stimu...
    Tai, Chun-Hwei; Tseng, Sheng-Hong

    Neurobiology of disease, December 2022, 2022-12-00, 20221201, 2022-12-01, Letnik: 175
    Journal Article

    Deep brain stimulation (DBS) conventionally target at basal ganglia or thalamic structures, modulating nodal points in the cortico-basal ganglia circuit, in order to effectively treat various movement disorders, including Parkinson's disease, tremor and dystonia (especially mobile type dystonia). However, there are still some other movement disorders, such as dystonia (especially fixed type dystonia), ataxia and freezing of gait, which are not responding well to the current DBS therapy. Cerebellum, similar to basal ganglia, also plays a critical role in the pathophysiology of movement disorders. Deep cerebellar structures, such as dentate nucleus or superior cerebellar peduncle, are noticed for their potential role as treatment targets in movement disorders in recent years. With increasing evidences of animal DBS experiments, recent clinical human subject studies reported that some movement disorders patients not responding to DBS with conventional targets, may benefit significantly from cerebellar DBS. These pioneer study results are invaluable for understanding the clinical use of cerebellar DBS for treatment of movement disorders. We review the recent data of cerebellar DBS performed by different groups and summarize the indications, surgical targets, programming details and outcomes in these clinical reports. We then synthesize the current pathophysiological study of cerebellum on different movement disorders and discuss the potential mechanism of action of cerebellar DBS. In addition to basal ganglia, it is important to study new DBS targets in the cerebellum for more comprehensive treatment of movement disorders. •Cerebellum plays a critical role in movement disorders, such as dystonia, tremor and ataxia.•Deep brain stimulation (DBS) targeting at cerebellum can be an effective tool to treat these movement disorders.•Key targets for cerebellar DBS include dentate nucleus (DN) and superior cerebellar peduncle (SCP).•Further exploration into the pathophysiology and the mechanisms of action are necessary for future development.