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Mader, Mary; de Dios, Alfonso; Shih, Chuan; Bonjouklian, Rosanne; Li, Tiechao; White, Wesley; de Uralde, Beatriz López; Sánchez-Martinez, Concepción; del Prado, Miriam; Jaramillo, Carlos; de Diego, Eugenio; Martín Cabrejas, Luisa M.; Dominguez, Carmen; Montero, Carlos; Shepherd, Timothy; Dally, Robert; Toth, John E.; Chatterjee, Arindam; Pleite, Sehila; Blanco-Urgoiti, Jaime; Perez, Leticia; Barberis, Mario; Lorite, María José; Jambrina, Enrique; Nevill, C. Richard; Lee, Paul A.; Schultz, Richard C.; Wolos, Jeffrey A.; Li, Li C.; Campbell, Robert M.; Anderson, Bryan D.
Bioorganic & medicinal chemistry letters, 2008, 2008-1-00, Letnik: 18, Številka: 1Journal Article
The p38 MAP kinase activity of two series of trisubstituted imidazoles (X = C, N) is reported, leading to compounds with highly potent cellular and in vivo activity. Herein we report investigations into the p38α MAP kinase activity of trisubstituted imidazoles that led to the identification of compounds possessing highly potent in vivo activity. The SAR of a novel series of imidazopyridines is demonstrated as well, resulting in compounds possessing cellular potency and enhanced in vivo activity in the rat collagen-induced arthritis model of chronic inflammation.
