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Renoux, R.; Demazieres, J. A.; Cardot, J. M.; Aiache, J. M.
Drug development and industrial pharmacy, 1996, Letnik: 22, Številka: 2Journal Article
Abstract The work reported here describes the improvement of an industrial production of tablets formed by direct compression. This formulation contained 50% active substance of plant origin as a nonhygroscopic powder. The first step was to evaluate a number of direct compression excipients in preformulation tests and then make up a basic formulation providing tablets with correct characteristics. The second step was the optimization of the initial formulation using a two-level factorial experimental design. This enabled the best formulations to be selected objectively.
