The security of water resources is the core content and ultimate goal of urban water resource management agencies. The management of water resources is directly related to the needs of urban residents’ lives and the area’s socio-economic development. How to determine the effective evaluation indicators and methods is an important prerequisite to solving the water resource security problem. This study took Luoyang City as the research area and constructed a water resource security evaluation index system based on pressure-state-response framework. An analytic hierarchy process and entropy weight method were used to determine the index weight. A set pair analysis model was then introduced to evaluate the security of water resources in Luoyang from 2006 to 2016. The results of this study show that the standard of water resource security generally improved in Luoyang in the latter years of the study period. From 2006 to 2008, Luoyang was graded at the Insecurity Level. This compares to a slightly improved grading of Critical Security Level from 2009 to 2016 (except for 2013). However, the overall grade is still low. The pressure on the Luoyang water resource system mainly comes from the development of the urban socio-economy, which in turn has caused problems for both the quantity and quality of water resources. Therefore, a series of countermeasures have been introduced as a means of improving the water resource security of Luoyang, and these measures have achieved certain results. However, further improvements to the efficiency of water resource utilization and strengthening the management and protection of water resources remain necessary.