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Chabaud, Mélanie; Paillon, Noémie; Gaus, Katharina; Hivroz, Claire
Biology of the cell, July 2020, 2020-Jul, 2020-07-00, 20200701, Letnik: 112, Številka: 7Journal Article
To mount an immune response, T cells must first find rare antigens present at the surface of antigen‐presenting cells (APCs). They achieve this by migrating rapidly through the crowded space of tissues and constantly sampling the surface of APCs. Upon antigen recognition, T cells decelerate and polarise towards the APC, ultimately forming a specialised interface known as the immunological synapse. These conjugates form as the result of the interaction between pairs of receptors/ligands that are under mechanical stress due to the continuously reorganising cell cytoskeleton. In this review, we discuss the involvement of mechanical forces during antigen recognition by migrating T cells. We will explore this question from a conceptual and technical perspective, with the aim of providing new insights into the emerging field of mechanobiology. Review: Antigen recognition by T cells leads to their arrest on the surface of antigen‐presenting cells. This event is associated with profound membrane and cytoskeletal remodelling that generate mechanical forces. This review explores our current knowledge of T cell mechanobiology and proposes additional conceptual and technical perspectives.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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