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Bhakta, Urmibhusan; Kattamuri, Padmanabha V; Siitonen, Juha H; Alemany, Lawrence B; Kürti, László
Organic letters, 11/2019, Letnik: 21, Številka: 22Journal Article
We report the first direct catalytic enantioselective allylation of acyclic α-ketiminoesters to afford α-allyl-α-aryl and α-allyl-α-trifluoromethyl amino esters in excellent isolated yield (91–99%) and with high optical purity (90–99+% ee). The allylation proceeds on a gram scale with 5–10 mol % of indium(I) iodide and commercially available BOX-type ligands. The allylated products are easily converted to enantiomerically enriched α-substituted proline derivatives.
