E-viri
Recenzirano
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Kyriazoglou, A.; Pagkali, A.; Kotsantis, I.; Economopoulou, P.; Kyrkasiadou, M.; Moutafi, M.; Gavrielatou, N.; Anastasiou, M.; Boulouta, A.; Pantazopoulos, A.; Giannakakou, M.; Digklia, A.; Psyrri, A.
Cancer treatment reviews, April 2024, 2024-Apr, 2024-04-00, 20240401, Letnik: 125Journal Article
•Anthracyclines remain the gold standard in first-line treatment challenged by molecular targets as mdm2 inhibitors.•PFS and OS endpoints have not been significantly raised with any of the approved second-line options.•Combinations of immunotherapy with TKIs show promising activity. Well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS) account for 60 % of all liposarcomas, reflecting the heterogeneity of this type of sarcoma. Genetically, both types of liposarcomas are characterized by the amplification of MDM2 and CDK4 genes, which indicates an important molecular event with diagnostic and therapeutic relevance. In both localized WDLPS and DDLPS of the retroperitoneum and the extremities, between 25 % and 30 % of patients have local or distant recurrence, even when perioperatively treated, with clear margins present. The systemic treatment of WDLPS and DDLPS remains a challenge, with anthracyclines as the gold standard for first-line treatment. Several regimens have been tested with modest results regarding their efficacy. Herein we discuss the systemic treatment options for WDLPS and DDLPS and review their reported clinical efficacy results.
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Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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