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Recenzirano
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Ma, Dong; Lin, Jiantao; Chen, Yuyun; Xue, Wei; Zhang, Li-Ming
Carbon (New York), 07/2012, Letnik: 50, Številka: 8Journal Article
Graphene oxide nanosheets were used to induce the in situ gelation of doxorubicin hydrochloride as an antitumor drug. When a very small amount of the graphene oxide was introduced into an aqueous solution of doxorubicin hydrochloride at room temperature, a strong and thixotropic gel was rapidly formed without any polymers or chemical additives. The gelation mechanism was investigated by fluorescence spectroscopy, X-ray diffraction and scanning electron microscopy. The encapsulated doxorubicin hydrochloride was found to show sustained release and antitumor efficacy.
