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Braun, L. A.; Varpetyan, E. E.; Zav’yalov, G. A.; Kulikov, F. V.; Marievskii, V. E.; Tyul’ganova, D. A.; Shishnenko, A. O.; Stepanova, D. S.; Shimanovskii, N. L.
Pharmaceutical chemistry journal, 09/2020, Letnik: 54, Številka: 6Journal Article
The awareness of malignant metabolism transformations has recently emerged. Since Otto Warburg found that tumor cells prefer glycolysis to oxidative phosphorylation even in the presence of oxygen, studies have shown that cancer cells also depend on upregulated fatty-acid synthesis and glutaminolysis. The present review covers the key metabolic enzymes known as metabolic oncogenes and suggests ways of modulating their activity. It is concluded that metabolic transformations during carcinogenesis present opportunities for targeted action on neoplasms and provide a new field for antitumor drug development.
