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  • Callyspongiolide, a Cytotox...
    Pham, Cong-Dat; Hartmann, Rudolf; Böhler, Philip; Stork, Björn; Wesselborg, Sebastian; Lin, Wenhan; Lai, Daowan; Proksch, Peter

    Organic letters, 01/2014, Letnik: 16, Številka: 1
    Journal Article

    A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes.