In this paper, two most representative hernia repair meshes were prepared with 0.15 mm polypropylene monofilaments via warp knitting technology, and their mechanical properties were tested in various aspects. Meanwhile, a focused investigation of the boundary conditions between the sutures and the mesh was simulated in several directions innovatively. The results revealed that the hernia repair mesh with different structures has different mechanical properties, and the mechanical properties of standard hernia repair mesh were superior to that of lightweight hernia repair mesh. In order to reduce foreign body sensation and postoperative adverse reactions significantly, the lightweight hernia repair mesh may be preferred. At the same time, the mesh should be placed in the proper direction to comply with the anisotropy of abdominal wall during operation. The area where the hernia mesh is in contact with the sutures was vulnerable to damage. The curved or wrinkled area of the hernia repair mesh increases with the increase of load, which may lead to poor tissue growth, a strong inflammatory response, and even the recurrence of the hernia. Therefore, the hernia repair meshes with different structures may require unique suture techniques. And they also should be further treated prior to implantation. This study provides a theoretical basis for development, utilization and improvement of meshes. Further research will focus on the biomechanical properties of the mesh after implantation in vivo studies.