...inevitably, I treat reactively, waiting until the neurological examination has worsened to proceed with surgery, allowing the intracranial pressure to become elevated prior to treating brain edema, or picking a group-based threshold for a physiological parameter, such as blood pressure or partial pressure of arterial carbon dioxide, and hoping that it is right for my specific patient. Clinical trials that test “one size fits all” approaches may trade a benefit (or harm) in individual patients for the goal of testing generalizability in a large heterogenous population of patients with a common overall condition, such as severe traumatic brain injury or spontaneous intracerebral hemorrhage. What I do not do is step away from the bedside and just provide a set of patient care orders for others (usually nurses and respiratory therapists) to follow similarly to a cookbook recipe. The idea of a dose–response relationship between depth and severity of a physiological event, such as elevated intracranial pressure or low blood pressure, is reasonably well accepted but not reported in most current purportedly advanced standard electronic medical records.