This paper proposes an innovative multi-scale method for determining gas pressure parameters of superplastic forming, which is based on the quantitative relationship between the grain growth mechanism and fracture mechanism of Ti-6Al-4V alloy. The high-temperature tensile tests were conducted on the material at temperatures ranging from 700, 800, 840, 890, 920, and 950°C, strain rates were selected as 10-2∼10-4/s. The grain size measurements were observed using electron back-scatter diffraction (EBSD). Particularly, the relation between grain size changes and fracture behaviour is specifically discovered using a physically-based dynamic material model (DMM), and the grain size thresholds for each forming limit are proposed. The physical fracture mechanism is named the "Grain growth based fracture (GGBF)" mechanism. Furthermore, an innovative method based on the GGBF mechanism is proposed to design the superplastic forming loading, and practical four-layer hollow structures experiments are applied to validate the fracture mechanism in superplastic forming. In total, A superplastic forming GGBF mechanism has been verified, and it is expected to be helpful for shape and property control in the forming process of complex structures. •An innovative multi-scale method for determining gas pressure parameters of superplastic forming, which is based on the quantitative relationship between the grain growth mechanism and fracture mechanism of Ti-6Al-4V alloy;•The relation between the grain size and fracture behavior has been discussed, and the fracture mechanism is named as "Grain growth based fracture (GGBF)" mechanism;•A practical four-layer hollow structure are performed, and the new multi-scale strategy is applied to determine the gas pressures.