•Densities of 3-aminopropan-1-ol and N-(2-hydroxyethyl)morpholine were measured.•Density and speed of sound for 3-aminopropan-1-ol and N-(2-hydroxyethyl)morpholine at ambient condition were measured.•Densities were correlated using the PC-SAFT equation of state and modified Tait equation.•Derived thermodynamic properties were predicted by the PC-SAFT and modified Tait equation. New density data has been reported for 3-aminopropan-1-ol (AP) and N-(2-hydroxyethyl)morpholine (NHEM) at temperatures ranging from (293.15–473.15) K at 19 pressures ranging from (0.1–40) MPa. The experimental measurements were carried out using an Anton Paar high-pressure vibrating tube densimeter with a combined expanded uncertainty of 1 kg m−3 at a 95 % confidence level. Contributions considered in the uncertainty analysis included the impurities in the materials used and apparatus specification. In addition, the density and speed of sound at ambient pressure (81.5 kPa) and temperatures (293.15–343.15) K were measured. The experimental density data were correlated with the modified Tait equation. Values of thermal expansion coefficient (αP ) and isothermal compressibility (κT) were calculated. The work is completed with the modeling of the experimental data using the perturbed-chain statistical associating fluid theory equation of state (PC-SAFT EOS). The parameters of the PC-SAFT equation of state, for the pure compounds, were determined by fitting the equation to the liquid PρT experimental data. Thermodynamic properties such as thermal expansion coefficient (αP), isothermal compressibility (κT), isobaric heat capacity (CP), and speed of sound (u) were calculated with the obtain parameters. Good agreement between experimental data and derived properties represented the modeling accuracy with the obtained parameters.