A porous hollow high-entropy metal organic framework (MOF-74) consisting of Mn, Fe, Co, Ni, Cu and Zn is prepared through one-pot hydrothermal method. Then, a high-entropy nanocomposite is prepared and evaluated as electrocatalyst for oxygen reduction reaction (ORR). The optimal nanocomposite comprising of metal-particle (Mn, Fe, Co, Cu), metal-alloy (Cu0·18Ni0.91, Co0·52Cu0.48) and metal-oxide (ZnO) exhibites very promising ORR performance due to the unique synergistic effect between multi-component high-entropy feature and hollow nanostructure. The approach of high-entropy nanocomposite is enlightening in developing high performance electrocatalysts. Display omitted •Hollow high-entropy metal organic frameworks consisiting of Mn, Fe, Co, Ni, Cu and Zn.•Porous high-entropy nanocomposite comprising of metals, alloys, metal oxides.•Synergistic effect of high-entropy and nanoporous hollow features leads to outstanding electrocatalytic oxygen reduction reaction activities.