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Ransohoff, Katherine J., BA; Jaju, Prajaka D., BA; Tang, Jean Y., MD, PhD; Carbone, Michele, MD, PhD; Leachman, Sancy, MD, PhD; Sarin, Kavita Y., MD, PhD
Journal of the American Academy of Dermatology, March 2016, Letnik: 74, Številka: 3Journal Article
Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings.
