Akademska digitalna zbirka SLovenije - logo
E-viri
Celotno besedilo
Recenzirano
  • Alternarin A, a Drimane Mer...
    Wang, Hong-Liang; Li, Ran; Li, Jiao; He, Jing; Cao, Zheng-Yu; Kurtán, Tibor; Mándi, Attila; Zheng, Gui-Liang; Zhang, Wen

    Organic letters, 04/2020, Letnik: 22, Številka: 8
    Journal Article

    Alternarin A (1), a rearranged drimane meroterpenoid characterized by a thioglycerate moiety, was isolated together with two known analogues from the coral-associated fungi Alternaria sp. ZH-15. Its structure was determined based on spectroscopic analysis, modified Mosher’s method, and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, compound 1 effectively inhibited the activity of spontaneous synchronous Ca2+ oscillations and 4-aminopyridine induced epileptic discharges in the low micromolar concentration range.