The present study focuses on the petrographic and petrological characteristics of mantle bodies included in Upper Cretaceous sedimentary melanges of the External Ligurian units (Northern Appennine), within the Monte Gavi and Monte Sant'Agostino areas. Two distinct pyroxenite-bearing mantle sections were recognized, mostly based on their plagioclase-facies evolution. The Monte Gavi mantle section is nearly undeformed and records a process of melt infiltration and reaction under plagioclase-facies conditions. The melt-rock interaction event involved both peridotites (mostly harzburgites) and enclosed spinel pyroxenite layers, and is estimated to have occurred at 0.7–0.8 GPa. In the Monte Gavi peridotites and pyroxenites, the spinel-facies clinopyroxene was partially replaced by plagioclase and new orthopyroxene (± secondary clinopyroxene). The reactive melt migration led to relatively high TiO2 contents in relict clinopyroxene and spinel (up to 2.3 wt% and 1.0 wt%, respectively, in the pyroxenites), with the latter also having high Cr# (up to 35 in the peridotites). The Monte Sant'Agostino mantle section displays a widespread ductile shearing and no evidence for melt-rock interaction under plagioclase-facies conditions. The main deformation phase recorded by the Monte Sant'Agostino peridotites (mostly lherzolites) is estimated to have occurred at 750–780 °C and 0.3–0.6 GPa, and gave rise to protomylonitic to ultramylonitic textures characterized by 10–50 μm neoblasts. The enclosed pyroxenite layers yielded relatively high temperature and pressure estimates (870–930 °C and 0.8–0.9 GPa). Presumably, in the Monte Sant'Agostino mantle section, plagioclase crystallization occurred earlier in the pyroxenites than in enclosing lherzolites, thereby enhancing strain localization and formation of mylonite shear zones in the entire mantle section. We propose that subcontinental mantle section from the External Ligurian units consists of three distinct mantle domains, developed in response to the rifting evolution that ultimately formed a Middle Jurassic ocean-continent transition: (1) a spinel tectonite domain that underwent no significant deformation and melt-rock reaction under plagioclase-facies conditions, characterized by static plagioclase development, (2) a plagioclase mylonite domain experiencing melt-absent deformation, and (3) a nearly undeformed domain that underwent melt infiltration and reaction under plagioclase-facies conditions. We relate mantle domains (1,2) to a rifting-driven uplift in the late Triassic accommodated by large-scale shear zones consisting of plagioclase mylonites. •Rifting evolution of two distinct peridotite-pyroxenite mantle sequences•Thermobarometry of plagioclase-facies mantle rocks•Reactive melt migration under plagioclase-facies conditions•Melt-absent ductile shearing and mylonite-ultramylonite formation•New constraints on the mantle evolution in the Western Tethys OCT