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  • Gold nanoparticles for regu...
    Bodelón, Gustavo; Costas, Celina; Pérez-Juste, Jorge; Pastoriza-Santos, Isabel; Liz-Marzán, Luis M.

    Nano today, April 2017, 2017-04-00, Letnik: 13
    Journal Article

    Display omitted •Living cells are sensor/actuator entities that perceive and process chemical and physical stimuli by receptor-mediated cell signaling, which in turn modulates cellular function and behavior.•Gold nanoparticles and gold nanostructured substrates have unique chemical and physical properties that allow targeted modulation of cell receptor function at the nanoscale.•Multifunctional gold-based nanodevices enable biochemical, plasmonic (e.g. optothermal) and electrical manipulation of cell activities at the nanoscale. The cell possesses the remarkable ability to perceive and process chemical and physical stimuli, which in turn modulate cellular behavior. One of the great wonders about nanotechnology is that it enables the fabrication of tools on the same length scale as biomolecules, thereby providing us with a unique handle for characterizing and controlling basic cellular processes. Owing to their tunable size and shape dependent physical properties, biocompatibility and facile surface modification, gold nanoparticles become potentially powerful tools to probe fundamental aspects of cell biology. Consequently, innovative approaches based on gold nanoparticles are under development toward the manipulation of cell function and improvement of techniques currently used in biomedicine and biotechnology. In this review we provide an overview of recent applications based on gold nanoparticles and nanostructured materials for the modulation of cellular activity and behavior, mediated by their interactions with cell surface receptors.