The COVID-19 pandemic and the Russian-Ukrainian war revealed vulnerabilities in supply chains, emphasizing the need for resilience in multiple industries. While Industry 4.0 is valuable, it cannot fully address complex supply chain challenges. Therefore, exploring additional drivers like Operations Management has become imperative. More clearly, the adoption of Operations Management tools and practices helps implement and use enabling technologies more effectively. In this context, the aim of the paper is to conduct a literature review to study supply chain resilience considering these two concepts. In other words, the objective of the work consists in examining the effectiveness of the mentioned combination. The paper presents a conceptual framework for enhancing supply chain resilience by exploring the potential of Industry 4.0 and Operations Management. The paper also underlines the positive impact issued from hybridizing both solutions to achieve resilience. As it discusses enhancing features of each concept aside the other. The paper provides a basic model for researchers to further detailed studies, and for managers to bringing the proposed framework from theory to practice.