E-viri
Recenzirano
-
Toure, Momar; Johnson, Theresa; Li, Bin; Schmidt, Ralf; Ma, Hong; Neagu, Constantin; Lopez, Andrea Unzue; Wang, Yanping; Guler, Satenig; Xiao, YuFang; Henkes, Renate; Ho, Kevin; Zhang, Susan; Chu, Chia Lin; Gundra, Uma Mahesh; Porichis, Filippos; Li, Long; Maurer, Christine Katharina; Fang, Zhizhou; Musil, Djordje; DiPoto, Maria; Friis, Emily; Jones, Reinaldo; Jones, Christopher; Cummings, James; Chekler, Eugene; Tanzer, Eva Maria; Huck, Bayard; Sherer, Brian
Bioorganic & medicinal chemistry, 09/2023, Letnik: 92Journal Article
Display omitted Hematopoietic progenitor kinase 1 (HPK1) is regarded as a highly validated target in pre-clinical immune oncology. HPK1 has been described as regulating multiple critical signaling pathway in both adaptive and innate cells. In support of this role, HPK1 KO T cells show enhanced sensitivity to TCR activation and HPK1 KO mice display enhanced anti-tumor activity. Taken together, inhibition of HPK1 has the potential to induce enhanced anti-tumor immune response. Herein, we described the discovery of highly potent HPK1 inhibitors starting form a weak HTS hit. Using a structure-based drug design, HPK1 inhibitors exhibiting excellent cellular single-digit nanomolar potency in both proximal (pSLP76) and distal (IL-2) biomarkers along with sustained elevation of IL-2 cytokine secretion were discovered.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.