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Royston, Daniel; Mead, Adam J.; Psaila, Bethan
Hematology/oncology clinics of North America, April 2021, 2021-04-00, Letnik: 35, Številka: 2Journal Article
Philadelphia-negative myeloproliferative neoplasms (MPNs) are an excellent tractable disease model of a number of aspects of human cancer biology, including genetic evolution, tissue-associated fibrosis, and cancer stem cells. In this review, we discuss recent insights into MPN biology gained from the application of a number of new single-cell technologies to study human disease, with a specific focus on single-cell genomics, single-cell transcriptomics, and digital pathology.
