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Liang, Yi; Ahmed, Musaddeque; Guo, Haiyang; Soares, Fraser; Hua, Junjie T; Gao, Shuai; Lu, Catherine; Poon, Christine; Han, Wanting; Langstein, Jens; Ekram, Muhammad B; Li, Brian; Davicioni, Elai; Takhar, Mandeep; Erho, Nicholas; Karnes, R Jeffrey; Chadwick, Dianne; van der Kwast, Theodorus; Boutros, Paul C; Arrowsmith, Cheryl H; Feng, Felix Y; Joshua, Anthony M; Zoubeidi, Amina; Cai, Changmeng; He, Housheng H
Cancer research (Chicago, Ill.), 10/2017, Letnik: 77, Številka: 20Journal Article
Androgen receptor (AR) signaling is a key driver of prostate cancer, and androgen-deprivation therapy (ADT) is a standard treatment for patients with advanced and metastatic disease. However, patients receiving ADT eventually develop incurable castration-resistant prostate cancer (CRPC). Here, we report that the chromatin modifier LSD1, an important regulator of AR transcriptional activity, undergoes epigenetic reprogramming in CRPC. LSD1 reprogramming in this setting activated a subset of cell-cycle genes, including CENPE, a centromere binding protein and mitotic kinesin. CENPE was regulated by the co-binding of LSD1 and AR to its promoter, which was associated with loss of RB1 in CRPC. Notably, genetic deletion or pharmacological inhibition of CENPE significantly decreases tumor growth. Our findings show how LSD1-mediated epigenetic reprogramming drives CRPC, and they offer a mechanistic rationale for its therapeutic targeting in this disease. .
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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