Increased wastewater production in the last several years has led to interest in new wastewater treatment technologies such as adsorption. This work evaluated the removal process of Zn2+/Cu2+ binary solutions using expanded vermiculite as alternative adsorbent. Assays were performed in dynamic systems to evaluate the influence of operating flow rate, adsorbate initial concentration and molar fraction on the adsorption process. Expanded vermiculite presented higher selectivity for zinc in single solutions as well as in binary system. •Copper and zinc binary adsorption in dynamic system was evaluated.•The optimum flow rate was obtained as 7mL/min.•Zinc was better removed than copper in binary dynamic system.•Vermiculite presented higher affinity and selectivity for zinc than for copper.