The concept of industry 4.0 (i4.0) encompasses the integration of different technologies into an autonomous, knowledge- and sensor-based, self-regulating production system. Our objective is to synthesize which are the challenges and opportunities of adopting i4.0 from the perspective of technology provider companies. A single-case research was conducted with ten companies at the Portuguese Production Technologies Cluster. Based on i4.0 technologies – Augmented reality; Additive Manufacturing; Big Data; Cloud Computing; Cyber-Physical Systems; Cybersecurity; Smart Robotics; Simulation; and System Integration – interviewees mentioned that the main adoption challenges are the analysis of data generated, integration of new technologies with available equipment and workforce, and computational limitations. The main opportunities are improvements in: efficiency; flexibility; productivity; cybersecurity; quality of products and services; and decision process due to data analysis. Interviewees have also foreseen changes in company's business model through the integration of internal resources with complementary activities of their partners and other cluster companies.