Display omitted •A novel, light-weight, refractory high-entropy alloy, AlNb2TiV was proposed.•The RHEA has a dendritic microstructure with single-phase B2.•The RHEA shows high specific strength and excellent room-temperature deformability. AlNb2TiV, a novel, light-weight, refractory high-entropy alloy (RHEA), with high specific strength and excellent room-temperature deformability is identified. As cast, it has a dendritic microstructure with an ordered B2 phase, low density (~6.19 g/cm3), excellent specific yield strength (167 MPa*cm3/g) and deformability (strain >1.0 in compression). Slip occurs by glide of 1/2〈111〉 dislocations. Based on previous work, the Ti/Nb ratio of our RHEA falls in the optimal range for easy dislocation motion and good deformability.