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Nayab Rasool, SK; Babu, P. Hari; Janaki Ramudu, D. B.; Jyothi Kumar, M. V.; Appa Rao, Ch; Raju, C. Naga
Phosphorus, sulfur, and silicon and the related elements, 01/2018, Letnik: 193, Številka: 1Journal Article
A series of new biologically active phenyl N,N ′ -phenyl phosphorodiamidates were synthesized by reacting phenyl phenylphosphoramidochoridate with various amines. All the newly synthesized compounds 3a-j were tested for their antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide (H 2 O 2 ) and nitric oxide (NO) methods. In all the three methods the compounds 3c (phenyl N-(6-methoxy-1,3-benzothiazol-2-yl)-N′-phenyl-phosphorodiamidate) and 3e (phenyl N-(5-ethyl-1,3,4-thiadiazol-2-yl)-N′-phenylphosphorodiamidate) showed good radical scavenging activity.
