Several standardized methods exist to determine formaldehyde (HCHO) release from wood-based panels (WBPs). These methods were developed decades ago to be used in manufacturers laboratories to provide a mean of production control. They are robust and take several hours to yield results. Modern WBP panel production, however, is a continuous process. Therefore the established methods are too time-consuming for process control and process optimization with respect to HCHO release. Moreover, there is a strong trend of lowering the regulatory HCHO emission limits. Thus, there is a need for a comparatively fast and precise method which is suitable for the use on-site in a WBP manufacturers laboratory. In this work, an optimization of the solid phase micro extraction gas chromatography high field asymmetric waveform ion mobility spectrometry (SPME-GC-FAIMS) method is presented with respect to GC-FAIMS settings and the calibration procedure. It is also shown that, in addition to WBP block samples, also particles can be used for the measurement. The industrial applicability of SPME-GC-FAIMS system was demonstrated by testing the HCHO release of freshly produced WBPs on-site in the manufacturers laboratory.