The comparative qualitative morphological study of bone fracture healing using etidronate-based preparation free of lanthanoids and in conjugation with them. The fragments of bone tissue from the facture zone were studied. They were obtained in 45 mongrel white rats on day 7, day 14, and day 30 after osteotomy in the zone of femoral shaft middle third. The investigation was performed by a morphological method in the three groups: (1) control, a fracture without treatment; (2) after paraosseous infusion of etidronate with lanthanoid and calcium ions; (3) after paraosseous infusion of etidronate with calcium ions without lanthanoids. The areas of leukocyte-necrotic masses with blood clots, those of granulation, connective and cartilaginous tissue, coarse-fibrous trabecular bone and lamellar bone, as well as those of necrotic bone parts were determined in the histological sections of the fracture zone with a morphometric grid. The data obtained were processed statistically. The best results of bone tissue healing for fractures were obtained when paraosseous infusing etidronate in combination with lanthanoids, and the effect of this was revealed just in the early periods after trauma. In this case, the intensity of injury-induced inflammatory reaction lowered and the volume of leukocyte-necrotic masses and traumatic edema decreased. The process of reparative regeneration accelerated as well with formation of granulation tissue and after that connective tissue and coarse-fibrous trabecular bone. Besides, indirect osteogenesis with bone formation through cartilaginous tissue was less common. As a result, there was uncomplicated fracture healing in most observations with the presented significant amount of formed compact and spongy lamellar bone. The combination of the etidronate-based preparation with lanthanoids is the most optimal, and its use is effective at all stages of bone fracture healing.