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Ferrarese, Roberto; Zuppardo, Raffaella Alessia; Puzzono, Marta; Mannucci, Alessandro; Amato, Virginia; Ditonno, Ilaria; Patricelli, Maria Grazia; Raucci, Annalisa Russo; Clementi, Massimo; Elmore, Ugo; Rosati, Riccardo; Testoni, Pier Alberto; Mancini, Nicasio; Cavestro, Giulia Martina
Journal of clinical medicine, 08/2020, Letnik: 9, Številka: 9Journal Article
Background: The role of microbiota in Lynch syndrome (LS) is still under debate. We compared oral and fecal microbiota of LS saliva and stool samples with normal healthy controls (NHC). Methods: Total DNA was purified from feces and saliva to amplify the V3–V4 region of the 16s rRNA gene. Sequences with a high-quality score and length >250 bp were used for taxonomic analysis with QIIME software. Results: Compared to NHC, LS fecal samples demonstrated a statistically significant increase of Bacteroidetes and Proteobacteria and a significant decrease of Firmicutes at the phylum level and of Ruminococcaceae at the family level. Moreover, LS oral samples exhibited a statistically significant increase of Veillonellaceae and Leptotrichiaceae and a statistically significant decrease of Pasteurellaceae. A beta-diversity index allowed differentiation of the two groups. Conclusions: A peculiar microbial signature is associated with LS, similar to that of sporadic colorectal cancer and Crohn’s disease. These data suggest a possible role of proinflammatory bacteria in tumor development in a condition of genetic predisposition, such as LS.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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