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Montalbán-Hernández, Karla; Casado-Sánchez, Cesar; Avendaño-Ortiz, José; Casalvilla-Dueñas, José Carlos; Bonel-Pérez, Gloria C.; Prado-Montero, Julia; Valentín-Quiroga, Jaime; Lozano-Rodríguez, Roberto; Terrón-Arcos, Verónica; de la Bastida, Fátima Ruiz; Córdoba, Laura; Laso-García, Fernando; Diekhorst, Luke; del Fresno, Carlos; López-Collazo, Eduardo
International journal of molecular sciences, 08/2022, Letnik: 23, Številka: 17Journal Article
Human-adipose-derived mesenchymal stem cells (hADMSCs) are multipotent stem cells which have become of great interest in stem-cell therapy due to their less invasive isolation. However, they have limited migration and short lifespans. Therefore, understanding the mechanisms by which these cells could migrate is of critical importance for regenerative medicine. Methods: Looking for novel alternatives, herein, hADMSCs were isolated from adipose tissue and co-cultured with human monocytes ex vivo. Results: A new fused hybrid entity, a foam hybrid cell (FHC), which was CD90+CD14+, resulted from this co-culture and was observed to have enhanced motility, proliferation, immunomodulation properties, and maintained stemness features. Conclusions: Our study demonstrates the generation of a new hybrid cellular population that could provide migration advantages to MSCs, while at the same time maintaining stemness properties.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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