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Guillon, Rémi; Pagniez, Fabrice; Picot, Carine; Hédou, Damien; Tonnerre, Alain; Chosson, Elizabeth; Duflos, Muriel; Besson, Thierry; Logé, Cédric; Le Pape, Patrice
ACS medicinal chemistry letters, 02/2013, Letnik: 4, Številka: 2Journal Article
Synthesis of a strict structural analogue of albaconazole in which the quinazolinone ring is fused by a thiazole moiety led to the discovery of a new triazole with broad-spectrum antifungal activity. Compound I exhibited high in vitro activity against pathogenic Candida species and filamentous fungi and showed preliminary in vivo antifungal efficacy in a mice model of systemic candidiasis.
