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Kameda, Takuro; Shide, Kotaro; Tahira, Yuki; Sekine, Masaaki; Sato, Seiichi; Ishizaki, Junzo; Takeuchi, Masanori; Akizuki, Keiichi; Kamiunten, Ayako; Shimoda, Haruko; Toyama, Takanori; Maeda, Kouichi; Yamashita, Kiyoshi; Kawano, Noriaki; Kawano, Hiroshi; Hidaka, Tomonori; Yamaguchi, Hideki; Kubuki, Yoko; Kitanaka, Akira; Matsuoka, Hitoshi; Shimoda, Kazuya
Viruses, 03/2022, Letnik: 14, Številka: 4Journal Article
A retrospective chart survey of the clinical features of indolent adult T-cell leukemia/lymphoma (ATL) was conducted in the Miyazaki Prefecture, Japan. This study enrolled 24 smoldering-type ATLs, 10 favorable chronic-type ATLs, and 20 unfavorable chronic-type ATLs diagnosed between 2010 and 2018. Among them, 4, 3, and 10 progressed to acute-type ATLs during their clinical course. The median survival time (MST) in smoldering-type ATL and favorable chronic-type ATL was not reached, and their 4-year overall survival (OS) was 73% and 79%, respectively. Compared with this, the prognosis of unfavorable chronic-type ATL was poor. Its MST was 3.32 years, and the 4-year OS was 46% (p = 0.0095). In addition to the three features that determine the unfavorable characteristics of chronic-type ATL, namely, increased lactate dehydrogenase, increased blood urea nitrogen, and decreased albumin, the high-risk category by the indolent ATL-Prognostic Index, which was defined by an increment of soluble interleukin-2 receptor (sIL2-R) of >6000 U/mL, could explain the poor prognosis in indolent ATL patients. The level of sIL-2R might be an indicator of the initiation of therapy for indolent ATL.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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