E-viri
Recenzirano
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Taniguchi, Koji; Karin, Michael
Seminars in immunology, 02/2014, Letnik: 26, Številka: 1Journal Article
Highlights • The IL-6 family of cytokines includes IL-6, IL-11, IL-27, IL-31, LIF, OSM, CNTF, CT-1 and CLC. • The IL-6 family of cytokines regulates cell proliferation, survival, migration, invasion, metastasis, angiogenesis and inflammation via gp130. • The JAK-STAT3 pathway is the major pathway downstream of gp130 signaling. • IL-6 and IL-11 are highly up-regulated in many cancers and are important mediators linking inflammation and cancer. • IL-6 and IL-11 are potential therapeutic and preventive targets as well as prognostic factors in cancer.
