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Mackall, Crystal L; Fleisher, Thomas A; Brown, Margaret R; Andrich, Mary P; Chen, Clara C; Feuerstein, Irwin M; Horowitz, Marc E; Magrath, Ian T; Shad, Aziza T; Steinberg, Seth M; Wexler, Leonard H; Gress, Ronald E
The New England journal of medicine, 01/1995, Letnik: 332, Številka: 3Journal Article
Depletion of CD4+ T lymphocytes is an important clinical problem in bone marrow transplantation 1 – 3 and human immunodeficiency virus (HIV) infection. 4 Yet the mechanisms by which CD4+ T lymphocytes regenerate are poorly understood. In 1961 Miller discovered the importance of the thymus in T-cell development in his studies of neonatally thymectomized mice. 5 Since then, extensive studies have elucidated the role of the thymus in fetal T-cell development, 6 and there has been a general acceptance of the view that the thymus plays an ongoing part in T-cell generation. This view underlies the concept that HIV infection of the thymus contributes to . . .
