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Chao, Nelson J; Schmidt, Gerhard M; Niland, Joyce C; Amylon, Michael D; Dagis, Andrew C; Long, Gwynn D; Nademanee, Auayporn P; Negrin, Robert S; O'Donnell, Margaret R; Parker, Pablo M; Smith, Eileen P; Snyder, David S; Stein, Anthony S; Wong, Ruby M; Blume, Karl G; Forman, Stephen J
New England journal of medicine/The New England journal of medicine, 10/1993, Letnik: 329, Številka: 17Journal Article
Acute graft-versus-host disease (GVHD) is a serious problem in recipients of allogeneic bone marrow grafts 1 . Several approaches have been used to prevent it. Removal of T cells that are responsible for acute GVHD 2 , 3 resulted in a lower incidence of this complication but a higher incidence of graft failure and relapse 3 , 4 . Another approach to the prophylaxis of acute GVHD is the use of immunosuppressive drugs such as methotrexate, cyclosporine, and cyclophosphamide, either singly or combined with other agents, including prednisone 5 – 10 . Recently, the use of intravenous immune globulin has also been shown to decrease the incidence . . .
