E-viri
Recenzirano
Odprti dostop
-
Kelly, Helen; Chikandiwa, Admire; Warman, Rhian; Segondy, Michel; Sawadogo, Bernard; Vasiljevic, Natasa; Didelot, Marie-Noelle; Meda, Nicolas; Weiss, Helen A; Delany-Moretlwe, Sinead; Mayaud, Philippe; Lorincz, Attila
AIDS (London), 09/2018, Letnik: 32, Številka: 15Journal Article
OBJECTIVES:To evaluate associations of DNA methylation of the human tumour suppressor gene EPB41L3 with high-grade cervical intraepithelial neoplasia (CIN2+) and HIV-related factors among women living with HIV-1 (WLHIV) in Burkina Faso (BF) and South Africa (SA). DESIGN:Case-control study of WLHIV aged 25–50 with histology-determined CIN2+ (cases, N = 152) and ≤CIN1 (controls, N = 210). METHODS:EPB41L3 methylation was measured by pyrosequencing of bisulfite converted DNA from exfoliated cervical specimens at baseline and 16 months later. Median methylation levels were compared across CIN grades using the Mann-Whitney test and Cuzick test for trend. EPB41L3 methylation levels were dichotomized into ‘high’ and ‘low’ using the 66.7 percentile point of the distribution in the controls. Associations of EPB41L3 methylation with HIV-related factors were estimated by logistic regression. RESULTS:Among 94 WLHIV in BF and 268 in SA, median methylation levels at baseline for EPB41L3 increased with increasing CIN grade in both countries (p-trend < 0.001).‘High’ methylation was more frequent among women with a longer time since HIV diagnosis in BF (>5 years vs. ≤5 years; adjusted Odds Ratio aOR = 4.15, 95%CI:1.09–15.83, adjusted for age, CD4+ count, HR-HPV and CIN status), with low CD4+ count in both countries (CD4+ ≤200 vs. ≥350 cells/mmaOR = 7.14, 95%CI:1.44–35.37 in BF; aOR = 2.55, 95%CI:1.07–6.07 in SA), and with prolonged ART use in SA (ART >2 years vs. ART-naïveaOR = 2.40, 95%CI:1.23–4.69). CONCLUSION:Methylation of EPB41L3 DNA is elevated among WLHIV with CIN2+ and independently associated with lower CD4+ count and ART use.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.