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Tyson, Jon E; Wright, Linda L; Oh, William; Kennedy, Kathleen A; Mele, Lisa; Ehrenkranz, Richard A; Stoll, Barbara J; Lemons, James A; Stevenson, David K; Bauer, Charles R; Korones, Sheldon B; Donovan, Edward F; Carlo, Waldemar A; Shankaran, Seetha; Stark, Ann R; Papile, Lu-Ann; Jobe, Alan; Stacewicz-Sapuntzakis, Maria; Verter, Joel; Fanaroff, Avroy A
New England journal of medicine/The New England journal of medicine, 06/1999, Letnik: 340, Številka: 25Journal Article
Infants with extremely low birth weights (≤1000 g) have low plasma and tissue concentrations of vitamin A, 1 – 3 and vitamin A deficiency may predispose these infants to chronic lung disease. 4 A meta-analysis 5 of clinical trials of vitamin A supplementation for preterm infants 6 – 9 revealed a 17 percent increase in the rate of survival without chronic lung disease, which approached statistical significance. The current relevance of these trials is limited by changes in the vitamin A concentration in infant formulas and by the use of antenatal glucocorticoid and postnatal surfactant therapy. Moreover, in a pilot study 5 we found that many infants . . .
