In viticulture, deficit irrigation strategies are often implemented to control vine canopy growth and to impose stress at critical stages of vine growth to improve wine grape quality. To support deficit irrigation scheduling, remote sensing technologies can be employed in the mapping of evapotranspiration (ET) at the field to sub-field scales, quantifying time-varying vineyard water requirements and actual water use. In the current study, we investigate the utility of ET maps derived from thermal infrared satellite imagery over a vineyard in the Central Valley of California equipped with a variable rate drip irrigation (VRDI) system which enables differential water applications at the 30 × 30 m scale. To support irrigation management at that scale, we utilized a thermal-based multi-sensor data fusion approach to generate weekly total actual ET (ETa) estimates at 30 m spatial resolution, coinciding with the resolution of the Landsat reflectance bands. Crop water requirements (ETc) were defined with a vegetative index (VI)-based approach. To test capacity to capture stress signals, the vineyard was sub-divided into four blocks with different irrigation management strategies and goals, inducing varying degrees of stress during the growing season. Results indicate derived weekly total ET from the thermal-based data fusion approach match well with observations. The thermal-based method was also able to capture the spatial heterogeneity in ET over the vineyard due to a water stress event imposed on two of the four vineyard blocks. This transient stress event was not reflected in the VI-based ETc estimate, highlighting the value of thermal band imaging. While the data fusion system provided valuable information, latency in current satellite data availability, particularly from Landsat, impacts operational applications over the course of a growing season.