The proposed methodology for optimizing energy efficiency, based on good management of the aeration process through the implementation of an appropriate control strategy, achieved reductions of more than 40% in energy consumption at the San Pedro del Pinatar Wastewater Treatment Plant (WWTP) (Murcia, Spain). Phases I and II of this methodology managed to reduce the oxygen needs of the microorganisms in the biological system, optimize the efficiency of oxygen transfer to the biological reactor and redesign the installation to correct abnormal energy loss situations. In addition, we established the basis for Phase III, which implemented a control strategy to achieve stable values close to the setpoints of the fundamental operating parameters of the aeration process. The control system is based on the measurements recorded by strategically installed sensors and mathematical algorithms based on models, achieving an expert adaptive-predictive system that regulates aeration both in the biological stage by activated sludge and the aeration of the installed ultrafiltration membrane system. The objectives were: (i) to achieve automatic execution of the best management strategy; (ii) to reduce the energy demand; (iii) to improve the operation and stability of the process; (iv) to reduce operating costs; and (v) to contribute to the fulfillment of the sustainable development objectives.