Purpose To review the history of indocyanine green (ICG) angiography and to present a personal perspective on its use in the clinical setting today. Design Perspective with literature review and opinions based on personal experience. Methods To acquire views from international retinal physicians experienced with the technique on uses in their facilities and to compare them to the author's personal standards. Results The author and contributing retinal physicians had surprisingly similar views for most, but not all, applications for ICG angiography use in the clinical setting. Conclusions ICG angiography is recommended for a few highly selective chorioretinal disorders, including certain forms of neovascularization in age-related macular degeneration, other neovascular maculopathies, chronic central serous chorioretinopathy, choroidal hemangiomas, and posterior uveitis.