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Simons, Lloyd J.; Caprathe, Bradley W.; Callahan, Michael; Graham, James M.; Kimura, Takenori; Lai, Yingjie; LeVine, Harry; Lipinski, William; Sakkab, Annette T.; Tasaki, Yoshikazu; Walker, Lary C.; Yasunaga, Tomoyuki; Ye, Yuyang; Zhuang, Nian; Augelli-Szafran, Corinne E.
Bioorganic & medicinal chemistry letters, 02/2009, Letnik: 19, Številka: 3Journal Article
It is believed that β-amyloid aggregation is an important event in the development of Alzheimer’s disease. In the course of our studies to identify β-amyloid aggregation inhibitors, a series of N-phenyl anthranilic acid analogs were synthesized and studied for β-amyloid inhibition activity. The synthesis, structure–activity relationship, and in vivo activity of these analogs are discussed. It is believed that β-amyloid aggregation is an important event in the development of Alzheimer’s disease. In the course of our studies to identify β-amyloid aggregation inhibitors, a series of N-phenyl anthranilic acid analogs were synthesized and studied for β-amyloid inhibition activity. The synthesis, structure–activity relationship, and in vivo activity of these analogs are discussed.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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