E-viri
PDF
Recenzirano
Odprti dostop
-
Oliveira, Maria T. A.; Teixeira, Alexandre M R.; Coutinho, Henrique D. M.; Menezes, Irwin R. A.; Sena, Diniz M.; Santos, Hélcio S.; de Mesquita, Bruna M; Albuquerque, Maria R. J. R.; Bandeira, Paulo N.; Braz-Filho, Raimundo
Natural product communications, 05/2014, Letnik: 9, Številka: 5Journal Article
The n-hexane extract of the stem bark of Croton anisodontus yielded 2-hydroxy-3,4,6-trimethoxyacetophenone, a well-known substance, but isolated from this species for the first time. The antimicrobial and modulatory activities of the compound towards Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, C krusei and C tropicalis strains were assessed. Antibiotics such as amikacin, gentamicin and neomycin were used in a subinhibitory concentration. Significant activity was observed towards P. aeruginosa and S. aureus 358, with p < 0.001 in association with amikacin. The present results place C anisodontus as an alternative source of 2-hydroxy-3,4,6-trimethoxyacetophenone with antibacterial potential.
