Transition metal dichalcogenides (TMDCs)‐based laminar membranes have gained significant interest in energy storage, fuel cell, gas separation, wastewater treatment, and desalination applications due to single layer structure, good functionality, high mechanical strength, and chemical resistivity. Herein, we review the recent efforts and development on TMDCs‐based laminar membranes, and focus is given on their fabrication strategies. Further, TMDCs‐based laminar membranes for water purification and seawater desalination are discussed in detail. Finally, present their merits, limits and future challenges needed in this area. This review focuses on recent progress on fabrication methods used for preparation of TMDCs‐based laminar membranes. Further, application of TMDCs‐based laminar membranes for desalination of sea and brakish water are discussed in detail. Finally, review ends with several recommendations and future directions.