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Liu, Chang; Tan, Fu-Xin; Zhou, Jia; Bai, He-Yuan; Ding, Tong-Mei; Zhu, Guo-Dong; Zhang, Shu-Yu
Organic letters, 03/2020, Letnik: 22, Številka: 6Journal Article
In general, enantioselective C–H functionalization of N-monosubstituted anilines is a highly challenging task owing to the competitive chemoselective N–H bond insertion reactions. In this paper, we reported a direct highly chemo-, site-, and enantioselective para C–H aminoalkylation of N-monosubstituted aniline derivatives with isatin-derived ketimines in the presence of chiral phosphoric acids (CPAs) and offered a practical strategy for para asymmetric C–H functionalization of anilines containing N–H bonds.
