Purpose Through‐time spiral GRAPPA is a real‐time imaging technique that enables ungated, free‐breathing evaluation of the left ventricle. However, it requires a separate fully‐sampled calibration scan to calculate GRAPPA weights. A self‐calibrated through‐time spiral GRAPPA method is proposed that uses a specially designed spiral trajectory with interleaved arm ordering such that consecutive undersampled frames can be merged to form calibration data, eliminating the separate fully‐sampled acquisition. Theory and Methods The proposed method considers the time needed to acquire data at all points in a GRAPPA calibration kernel when using interleaved arm ordering. Using this metric, simulations were performed to design a spiral trajectory for self‐calibrated GRAPPA. Data were acquired in healthy volunteers using the proposed method and a comparison electrocardiogram‐gated and breath‐held cine scan. Left ventricular functional values and image quality are compared. Results A 12‐arm spiral trajectory was designed with a temporal resolution of 32.72 ms/cardiac phase with an acceleration factor of 3. Functional values calculated using the proposed method and the gold‐standard method were not statistically significantly different (paired t‐test, p < 0.05). Image quality ratings were lower for the proposed method, with statistically significantly different ratings (Wilcoxon signed rank test, p < 0.05) for two of five image quality aspects rated (level of artifact, blood‐myocardium contrast). Conclusions A self‐calibrated through‐time spiral GRAPPA reconstruction can enable ungated, free‐breathing evaluation of the left ventricle in 71 s. Functional values are equivalent to a gold‐standard cine technique, although some aspects of image quality may be inferior due to the real‐time nature of the data collection.