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Vyas, Komal M.; Jadeja, R.N.; Patel, Dipak; Devkar, R.V.; Gupta, Vivek K.
Polyhedron, 11/2013, Letnik: 65Journal Article
The synthesis of a new ternary complex Cu(TMCPMP-TS)(Phen), with its crystal structure, has been reported. DNA binding, protein binding and anti-cancer studies of the complex has been carried out. With the aim of exploring the anticancer properties of coordination compounds, we report for the first time the synthesis of the new ternary complex Cu(TMCPMP-TS)(Phen) (TMCPMP-TS; (Z)-2-((1-(3-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)(p-tolyl)methylene) hydrazinecarbothioamide and Phen; 1,10-phenanthroline). The complex was characterized by various techniques, including X-ray crystallography which showed that the geometry of the metal centre was between square pyramidal and trigonal bipyramidal. The interaction with calf-thymus DNA showed binding through intercalation. The protein binding ability with bovine serum albumin revealed a stronger binding of complex as compared to the free ligands. The anticancer activity of the complex was investigated by exposing it to the A549 (human lung cancer) cell line, which showed mitochondrial damage via an oxidative mechanism. After 24h treatment, the complex arrested S and G2/M phases in the cell cycle progression and induced cell death. The results envisaged herein indicate that Cu(TMCPMP-TS)(Phen) holds ample merit to develop it as a therapeutic agent against cancer.
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