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  • Heterocycle Synthesis via D...
    Nadres, Enrico T; Daugulis, Olafs

    Journal of the American Chemical Society, 01/2012, Letnik: 134, Številka: 1
    Journal Article

    A method for five- and six-membered heterocycle formation by palladium-catalyzed C–H/N–H coupling is presented. The method employs a picolinamide directing group, PhI(OAc)2 oxidant, and toluene solvent at 80–120 °C. Cyclization is effective for sp2 as well as aliphatic and benzylic sp3 C–H bonds.