E-viri
Recenzirano
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Scheller, Jürgen; Garbers, Christoph; Rose-John, Stefan
Seminars in immunology, 02/2014, Letnik: 26, Številka: 1Journal Article
Highlights • The IL-6 receptor can be shed from the cellular membrane by the protease ADAM17. • The complex of IL-6 and IL-6 receptor induces signaling on cells only expressing gp130, a process has been named trans-signaling. • IL-6 trans-signaling can be specifically blocked by soluble gp130. • IL-6 trans-signaling is pro-inflammatory whereas IL-6 signaling via the membrane bound IL-6 receptor is regenerative and protects from bacterial infections. • A soluble gp130Fc protein has been developed as an anti-inflammatory drug, which is currently tested as in phase I clinical trials.
